Phone

Supplements

Pyruvate

What is it?

Pyruvate is a salt form of pyruvic acid, a naturally occuring chemical that is important in the energy-generating reaction in animal cells know as the Kreb's cycle.

Health Benefits

Claims , based on very limited research, have been made that pyruvate can assist with weight loss. The actual studies used large amounts of pyruvate in a variety of patients with obesity or high blood fats, making it difficult to predict  the results of pyruvate supplementation in the general population concerned with simple weight managment.(1,2,3,4,5) For this reason, WholeHealthmd.com does not recommend the use of pyruvate except under the supervision of a health care practitioner.

Cautions

The large doses of pyruvate used in the human trials caused intestinal symptoms of diarrhea, and gas in some participants.(3,4,5)  

References

1. Stanko RT, Reynolds HR, Hoyson R, et al. Pyruvate supplementation of a low-cholesterol, low-fat diet: effects on plasma lipid concentrations and body composition in hyperlipidemic patients. Am J Clin Nutr. 1994;59:423–427.

2. Kalman D, Colker CM, Stark S, et al. Effect of pyruvate supplementation on body composition and mood. Curr Ther Res. 1998;59:793–802.

3. Stanko, R.T., D.L. Tietze, and J.E. Arch. Body composition, energy utilization, and nitrogen metabolism with a 4.25-MJ/d low-energy diet supplemented with pyruvate. Am. J. Clin. Nutr. 56: 630-635, 1992.

4. Stanko, R.T., D.L. Tietze, and J.E. Arch. Body composition, energy utilization, and nitrogen metabolism with a severely restricted diet supplemented with dihydroxyacetone and pyruvate. Am. J. Clin. Nutr. 55: 771-776, 1992.

5. Stanko, R.T., and J.E. Arch. Inhibition of regain in body weight and fat with addition of 3-carbon compounds to the diet with hyperenergetic refeeding after weight reduction. Int. J. Obes. 20: 925-930, 1996.


Date Published: 09/25/2008
Previous  |  Next
> Printer-friendly Version Return to Top