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Drugs

Side Effects
Serious

If you have severe or worsening constipation while taking alosetron, stop using it immediately and call your doctor. Rarely, acute ischemic colitis (insufficient flow of blood to the colon) has been reported in some patients taking alosetron. The exact relationship between this drug and acute colitis has not been determined. However, if you experience rectal bleeding or bloody diarrhea, low-grade fever, and abdominal distention and tenderness, discontinue alosetron and contact your doctor immediately.
Common

Constipation.
Less Common

High blood pressure, runny nose, nausea, abdominal discomfort and pain, gas, increased susceptibility to viral gastrointestinal infections, heartburn, abdominal swelling, hemorrhoids, sleep problems, depression
Alosetron Hydrochloride


Drug Class:
Selective 5-HT3 (serotonin) receptor antagonist

Available OTC?: No

Available Generic?: No

Available In
Why Prescribed
How It Works
Range and Frequency
Onset of Effect
Duration of Action
Dietary Advice
Storage
Missed Dose
Stopping the Drug
Prolonged Use
Over 60
Driving and Hazardous Work
Alcohol
Pregnancy
Breast Feeding
Infants and Children
Special Concerns
Overdose Symptoms
What to Do
Drug Interactions
Food Interactions
Disease Interactions


Available In
Tablets

Why Prescribed
To treat irritable bowel syndrome (IBS) in women whose primary symptom is diarrhea. (Alosetron has not been shown to be effective in men.) NOTE: Due to reports of rare but serious side effects, the drug's manufacturer, Glaxo Wellcome, has voluntarily removed it from the market as of November 28, 2000. If you currently use alosetron, consult your doctor about alternative medications as soon as possible.

How It Works
By blocking the action of serotonin, alosetron inhibits the excitation of nerves along the gastrointestinal tract that may be hypersensitive in IBS sufferers. It also slows the movement of food through the bowel and may ease the pain and discomfort of IBS.

Range and Frequency
1 mg twice a day.

Onset of Effect
one to four weeks.

Duration of Action
Alosetron is effective as long as you continue to take the medication.

Dietary Advice
Alosetron may be taken with or without food.

Storage
Store in a tightly sealed container away from heat, moisture, and direct light.

Missed Dose
Take it as soon as you remember. However, if it is near the time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose.

Stopping the Drug
The decision to stop taking the drug should be made in consultation with your physician. Because alosetron does not cure IBS or work for everyone, quit using it if your symptoms do not improve within 4 weeks.

Prolonged Use
The safety and efficacy of alosetron for treatment beyond 12 months have not been established.

Over 60
No special problems are expected.

Driving and Hazardous Work
No special precautions are necessary.

Alcohol
Avoid alcohol while taking this medication, as it may aggravate your condition.

Pregnancy
In animal tests, alosetron has not caused problems. Human tests have not been done. Before you take alosetron, tell your doctor if you are pregnant or plan to become pregnant.

Breast Feeding
Alosetron may pass into breast milk; caution is advised. Consult your doctor for advice on whether to discontinue nursing or discontinue the drug.

Infants and Children
The safety and effectiveness of this drug have not been established for children under the age of 18.

Special Concerns
When you stop taking alosetron, IBS symptoms are likely to return within one week.

Overdose Symptoms
No cases of overdose have been reported. However, symptoms may include difficulty breathing, subdued behavior, coordination difficulties, tremor, and seizures.

What to Do
If you suspect an overdose or if someone takes a much larger dose than prescribed, call your doctor, emergency medical services (EMS), or the nearest poison control center immediately.

Drug Interactions
No known drug interactions.

Food Interactions
No known food interactions.

Disease Interactions
Do not start taking alosetron when you are constipated or if you are constipated most of the time. Do not take alosetron if you have a history of ischemic colitis or other intestinal disorders, such as Crohn?s disease, ulcerative colitis, or active diverticulitis.

Date Published: 05/23/2005
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