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Drugs

Side Effects
Serious

Bleeding problems; small, red pinpoints on the skin; fever; extreme fatigue; bleeding ulcers in the rectum, mouth, and vagina; reduced white blood cell count (rare).
Common

Drowsiness; unusual excitability; dry mouth, nose, or throat. Symptoms of drowsiness tend to subside after a few days' use as your body adjusts to the drug.
Less Common

Vision changes, loss of appetite, dizziness, painful or difficult urination, less tolerance for contact lenses.
Brompheniramine Maleate


Drug Class:
Antihistamine

Available OTC?: Yes

Available Generic?: Yes

Available In
Why Prescribed
How It Works
Range and Frequency
Onset of Effect
Duration of Action
Dietary Advice
Storage
Missed Dose
Stopping the Drug
Prolonged Use
Over 60
Driving and Hazardous Work
Alcohol
Pregnancy
Breast Feeding
Infants and Children
Special Concerns
Overdose Symptoms
What to Do
Drug Interactions
Food Interactions
Disease Interactions


Available In
Capsules, tablets, extended-release tablets, elixir, injection

Why Prescribed
To prevent or relieve symptoms of hay fever, other allergies, itching skin, or hives.

How It Works
Brompheniramine blocks the effects of histamine, a substance in the body that causes swelling, itching, sneezing, watery eyes, hives, and other symptoms of allergic reaction.

Range and Frequency
Capsules, tablets, elixir-- Adults and teenagers: 4 mg every 4 to 6 hours. Children ages 6 to 12: 2 mg every 4 to 6 hours. Children ages 2 to 6: 1 mg every 4 to 6 hours. Extended-release tablets-- Adults: 8 mg every 8 to 12 hours, or 12 mg every 12 hours. Children age 6 and older: 8 or 12 mg every 12 hours. Injection-- Adults and teenagers: 10 mg under the skin or into a vein or muscle every 8 to 12 hours. Children younger than age 12: 0.125 mg per 2.2 lbs (1 kg) of body weight, under the skin or into a vein or muscle 3 or 4 times a day.

Onset of Effect
15 to 60 minutes.

Duration of Action
3 to 6 hours for regular form; 8 to 12 for extended-release tablets.

Dietary Advice
Take it with food or milk to minimize stomach upset.

Storage
Store in a tightly sealed container away from heat and direct light.

Missed Dose
Take it as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose.

Stopping the Drug
You should take it as prescribed for the full treatment period, but you may stop if you feel better before the scheduled end of therapy. It may be taken as needed.

Prolonged Use
No special concerns.

Over 60
Older persons are more sensitive to antihistamine side effects, particularly confusion, dizziness, drowsiness, restlessness, irritability, nightmares, and dry mouth, nose, and throat.

Driving and Hazardous Work
Brompheniramine can make you feel tired and lessen your concentration. Do not drive or engage in hazardous work until you determine how the drug affects you.

Alcohol
Alcohol increases the likelihood and the severity of side effects like drowsiness and confusion.

Pregnancy
Studies in animals suggest that brompheniramine has no adverse effect on fetal development, but human studies have not been done. Before taking this drug, tell your doctor if you are pregnant or are planning to become pregnant.

Breast Feeding
Brompheniramine passes into breast milk; avoid or discontinue use while breast feeding.

Infants and Children
Brompheniramine should be given to children age 6 and under only as directed by a doctor.

Special Concerns
Do not break, crush, or chew the capsules or the extended-release tablets.

Overdose Symptoms
Seizures, loss of consciousness, hallucinations, severe drowsiness.

What to Do
The patient should be made to vomit immediately, using ipecac syrup. If he or she is unconscious, the patient should be taken to a hospital emergency room immediately.

Drug Interactions
MAO inhibitors can increase the sedative effects of brompheniramine. Central nervous system depressants such as alcohol, sedatives, or narcotics should be taken only if approved by a doctor.

Food Interactions
No known food interactions.

Disease Interactions
Before taking brompheniramine, consult your doctor if you wear contact lenses or you have glaucoma, prostate enlargement, difficulty with urination, or dryness of the mouth or eyes.

Date Published: 04/13/2005
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