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Drugs

Side Effects
Serious

Rapid or irregular heartbeat, dry mouth, increased thirst, mood or mental changes, muscle cramps or pain, nausea or vomiting, unusual fatigue, black and tarry stools, buzzing or ringing in ears, hearing loss, skin rash. Call your doctor immediately.
Common

Muscle cramps. Fluid depletion can cause dizziness when the patient rises from a sitting or lying position, as well as thirst and constipation. Minor potassium depletion can cause mild weakness, and rapid or irregular heartbeat.
Less Common

Gout, increased blood sugar (glucose) levels, hearing loss.
Bumetanide


Drug Class:
Loop diuretic

Available OTC?: No

Available Generic?: Yes

Generic 0.5 mg
(Zenith)
Available In
Why Prescribed
How It Works
Range and Frequency
Onset of Effect
Duration of Action
Dietary Advice
Storage
Missed Dose
Stopping the Drug
Prolonged Use
Over 60
Driving and Hazardous Work
Alcohol
Pregnancy
Breast Feeding
Infants and Children
Special Concerns
Overdose Symptoms
What to Do
Drug Interactions
Food Interactions
Disease Interactions



Available In
Tablets, injection

Why Prescribed
To reduce the accumulation of fluid (containing salts and water) that leads to edema (swelling) and breathlessness in patients with heart disease, cirrhosis of the liver, and kidney disease. Bumetanide may also be used to help control high blood levels of potassium.

How It Works
Loop diuretics work on a specific portion of the kidney (the loop of Henle) to increase the excretion of both water and sodium in the urine.

Range and Frequency
0.5 to 6 mg per day, usually taken in the morning; may be increased to 2 to 3 doses a day, as needed.

Onset of Effect
This drug begins eliminating excess water within 1 to 2 hours.

Duration of Action
Up to 4 hours.

Dietary Advice
Bumetanide can be taken with or after meals to reduce stomach irritation.

Storage
Store in a tightly sealed container away from heat and direct light.

Missed Dose
If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. In that case, skip the missed dose and return to your regular schedule. Do not double the next dose.

Stopping the Drug
Take it as prescribed for the full treatment period, even if you begin to feel better before the scheduled end of therapy. The decision to stop taking the drug should be made by your doctor.

Prolonged Use
Prolonged use of bumetanide requires regular examinations by your doctor, since it may lead to imbalances of sodium, potassium, magnesium, and body fluid.

Over 60
No special problems are expected.

Driving and Hazardous Work
No special precautions are necessary.

Alcohol
No special precautions are necessary.

Pregnancy
Adequate studies of using this drug during pregnancy have not been done. Before taking this drug, tell your doctor if you are pregnant or plan to become pregnant. If diuretic treatment is warranted, other drugs are preferred.

Breast Feeding
This drug may pass into breast milk. Consult your doctor about its use while nursing.

Infants and Children
This drug is not generally prescribed for children. Its safety and effectiveness for anyone under the age of 18 have not been established.

Special Concerns
You may have to take a potassium supplement or consume foods or fluids high in potassium while taking this drug. To prevent disruption of sleep, avoid taking this drug in the evening.

Overdose Symptoms
Severe fatigue, weakness, lethargy, confusion, muscle cramps, nausea, vomiting, weak and rapid pulse, loss of consciousness.

What to Do
Call your doctor, emergency medical services (EMS), or the nearest poison control center immediately.

Drug Interactions
Consult your doctor about any other drugs you are taking, particularly antibiotics, other blood pressure medications (especially ACE inhibitors), analgesics (pain relievers), lithium, cortisone-related drugs, digitalis drugs, or any nonsteroidal anti-inflammatory drug (NSAID).

Food Interactions
No food interactions have been documented.

Disease Interactions
Caution is advised when taking bumetanide. Consult your doctor if you have any of the following: diabetes, gout, a hearing problem, or a recent heart attack.

Date Published: 04/13/2005
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