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Drugs

Side Effects
Serious

Heartbeat irregularities, lightheadedness (caused by high blood potassium levels). Notify your doctor at once.
Common

There are no common side effects associated with the use of amiloride.
Less Common

Headache, nausea, loss of appetite, weight loss, diarrhea, vomiting, weakness, dizziness, drowsiness, abdominal pain, constipation, impotence, increased skin sensitivity to sunlight, nervousness, irregular heartbeat, shortness of breath, tingling in hands, feet, or lips.
Amiloride Hydrochloride


Drug Class:
Potassium-sparing diuretic

Available OTC?: No

Available Generic?: Yes

Midamor 5 mg
(Merck)
Available In
Why Prescribed
How It Works
Range and Frequency
Onset of Effect
Duration of Action
Dietary Advice
Storage
Missed Dose
Stopping the Drug
Prolonged Use
Over 60
Driving and Hazardous Work
Alcohol
Pregnancy
Breast Feeding
Infants and Children
Overdose Symptoms
What to Do
Drug Interactions
Food Interactions
Disease Interactions



Available In
Capsules, tablets

Why Prescribed
As adjunctive (supplementary) treatment with other diuretics to increase excretion of sodium and water in the urine, while conserving potassium.

How It Works
Amiloride promotes loss of sodium and water from the body by altering kidney enzymes that control urine production. Unlike other types of diuretics, amiloride belongs to a class that promotes excretion of excess water but does not deplete normal levels of potassium. In conjunction with thiazide or loop diuretics, amiloride reduces the overall fluid volume in the body and helps to control symptoms of heart disease, kidney disease, and liver disease.

Range and Frequency
In most cases, 5 mg a day, increased to 10 mg a day if necessary. Maximum dose is 20 mg a day. The drug is usually taken in one daily dose, preferably in the morning.

Onset of Effect
Two to four hours.

Duration of Action
Up to 24 hours.

Dietary Advice
Amiloride can be taken with liquid or food to lessen stomach irritation. Avoid large quantities of high-potassium foods (see Food Interactions).

Storage
Store in a tightly sealed container away from heat and direct light.

Missed Dose
Take it as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose.

Stopping the Drug
The decision to stop taking the drug should be made by your doctor.

Prolonged Use
No apparent problems.

Over 60
No special precautions are warranted.

Driving and Hazardous Work
No special precautions are necessary.

Alcohol
No special precautions are necessary.

Pregnancy
Animal studies have not shown birth defects. Adequate human studies have not been done. Consult your doctor about taking amiloride during pregnancy.

Breast Feeding
It is not known whether amiloride passes into breast milk. Consult your doctor about its use while nursing.

Infants and Children
A small dose (0.625 mg per day) may be used in young children.

Overdose Symptoms
Rapid, irregular heartbeat, shortness of breath, nervousness, confusion, weakness, stupor.

What to Do
Call your doctor, emergency medical services (EMS), or the nearest poison control center immediately.

Drug Interactions
Tell your doctor if you are taking other drugs, especially ACE inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), digoxin, lithium, potassium supplements, another diuretic, cyclosporine, or tacrolimus.

Food Interactions
Avoid consuming large servings of high-potassium foods, which include bananas, citrus fruits and juices, melons, prunes, (and most fruits in general), avocados, potatoes, nuts, baked beans, brussels sprouts, and skim milk.

Disease Interactions
Caution is advised when taking amiloride. Consult your doctor if you have any of the following: diabetes mellitus, gout, kidney stones, liver disease, or kidney disease.

Date Published: 04/13/2005
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