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Side Effects
Serious

Retention of urine (decreased urine output), confusion, disorientation.
Common

Blurred vision, drowsiness, agitation, dry mouth, constipation, urine retention. Constipation can be avoided by increasing the intake of fluids and high-fiber foods. Dry mouth can be relieved by cool drinks, sugarless gum, or hard candy.
Less Common

Restlessness, irritability or unusual feeling of well-being, dizziness, tremor, stomach upset, nausea.
Biperiden


Drug Class:
Antiparkinsonism drug

Available OTC?: No

Available Generic?: Yes

Akineton 2 mg
(Knoll)
Available In
Why Prescribed
How It Works
Range and Frequency
Onset of Effect
Duration of Action
Dietary Advice
Storage
Missed Dose
Stopping the Drug
Prolonged Use
Over 60
Driving and Hazardous Work
Alcohol
Pregnancy
Breast Feeding
Infants and Children
Special Concerns
Overdose Symptoms
What to Do
Drug Interactions
Food Interactions
Disease Interactions


Available In
Tablets, injection

Why Prescribed
To treat Parkinson's disease or the side effects of certain drugs that act on the central nervous system and produce Parkinson-like symptoms, including slowed movement, stiffness, and loss of balance.

How It Works
The exact mechanism of action is unknown, but biperiden is believed to help increase the release of certain neurological chemicals that improve control over movement.

Range and Frequency
Tablets: For Parkinson's disease, 2 mg, 3 or 4 times per day, to a maximum of 16 mg per day. For side effects of other drugs, 2 mg, 1 to 3 times per day. If you have difficulty swallowing the tablet, it can be crushed. Injection: 2 mg up to 4 times per day, injected into a muscle or vein. The maximum dose should not exceed 10 mg per day.

Onset of Effect
Within 1 hour.

Duration of Action
6 to 12 hours with tablets; 1 to 8 hours after injection.

Dietary Advice
Take this medicine with or immediately after meals unless your doctor orders otherwise.

Storage
Store in a tightly sealed container away from heat and direct light.

Missed Dose
If you miss a dose, take it as soon as you remember unless it is within 2 hours of the next dose. In that case, skip the missed dose and return to your regular schedule. Do not double the next dose.

Stopping the Drug
Do not stop taking the drug suddenly. If therapy is to be discontinued, the dosage should be reduced gradually, according to your doctor's instructions, to avoid a withdrawal reaction.

Prolonged Use
Your doctor should test your progress regularly so that the dose can be adjusted if necessary.

Over 60
Side effects may be more common in older persons. A reduced dose may be necessary. This medicine can aggravate symptoms of an enlarged prostate gland and cause impaired thinking, hallucinations, and nightmares in older persons.

Driving and Hazardous Work
Determine how this medicine affects you before driving or engaging in hazardous work.

Alcohol
Alcohol intake should be avoided because this medicine increases its effects.

Pregnancy
Do not use this drug while pregnant.

Breast Feeding
Do not use this drug while breast feeding.

Infants and Children
Safety and effectiveness have not been established for infants and children.

Special Concerns
Pay careful attention to dental hygiene, since biperiden tends to decrease salivation, which can promote the development of cavities and other dental problems.

Overdose Symptoms
Agitation, anxiety, restlessness, disorientation, hallucinations, blurred vision, fast pulse, difficulty swallowing, and difficulty urinating.

What to Do
Call your doctor, emergency medical services (EMS), or the nearest poison control center immediately.

Drug Interactions
Tell your doctor about any other drugs you are taking, especially amantadine, digoxin, any drug for mental illness, antidepressants, or antacids. This medicine can decrease the activity of phenothiazines (mood-altering drugs used in the treatment of psychiatric disorders).

Food Interactions
No known food interactions.

Disease Interactions
Glaucoma, seizures, an irregular pulse, a bowel obstruction, or an enlarged prostate may make it impossible for you to take this medicine.

Date Published: 04/13/2005
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