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Drugs

Side Effects
Serious

Severe generalized reactions involving the skin, liver, and blood cells. Discontinue using the medication and call your doctor immediately if signs of serious reaction occur.
Common

Burning, stinging, or discomfort in the eye or blurred vision when drug is administered; bitter taste in mouth.
Less Common

Eye pain, severe or continued tearing, nausea.

 

Brinzolamide


Drug Class:
Antiglaucoma agent; carbonic anhydrase inhibitor

Available OTC?: No

Available Generic?: No

Available In
Why Prescribed
How It Works
Range and Frequency
Onset of Effect
Duration of Action
Dietary Advice
Storage
Missed Dose
Stopping the Drug
Prolonged Use
Over 60
Driving and Hazardous Work
Alcohol
Pregnancy
Breast Feeding
Infants and Children
Special Concerns
Overdose Symptoms
What to Do
Drug Interactions
Food Interactions
Disease Interactions


Available In
Ophthalmic suspension

Why Prescribed
To treat glaucoma or ocular hypertension (a glaucoma-like condition).

How It Works
Glaucoma and ocular hypertension, both sight-threatening disorders, occur when poor drainage of aqueous humor (the fluid inside the front part of the eye) increases the pressure within the eyeball (known as intraocular pressure). Increased intraocular pressure can damage the optic nerve and lead to a gradual loss of vision. By inhibiting the activity of the enzyme carbonic anhydrase, brinzolamide decreases the production of aqueous humor, and reduces intraocular pressure.

Range and Frequency
Adults and teenagers: 1 drop in affected eye(s) 3 times per day.

Onset of Effect
Unknown.

Duration of Action
Unknown.

Dietary Advice
No special restrictions.

Storage
Store in a tightly sealed container away from heat, moisture, and direct light. Do not refrigerate or allow it to freeze.

Missed Dose
Apply it as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose.

Stopping the Drug
The decision to stop using the drug should be made by your doctor.

Prolonged Use
Schedule regular eye examinations with your doctor to be sure the drug is controlling the glaucoma or ocular hypertension.

Over 60
No special problems are expected.

Driving and Hazardous Work
Do not drive or engage in hazardous work until you determine how the medicine affects your vision.

Alcohol
No special precautions are necessary.

Pregnancy
One animal study found that very high doses of this drug caused birth defects. Human studies have not been done. Before using this medicine, tell your doctor if you are pregnant or plan to become pregnant.

Breast Feeding
It is not known whether brinzolamide passes into breast milk; caution is advised. Consult your doctor for specific advice about whether to use a different medicine or to stop breast feeding.

Infants and Children
Safety and dosage for children have not been established. Brinzolamide should be given to infants and children only under close medical supervision.

Special Concerns
To use the eye drops, first wash your hands. Tilt your head back. Gently apply pressure to the inside corner of the eyelid and with the index finger of the same hand, pull downward on the lower eyelid to make a space. Drop the medicine into this space and close your eye. Apply pressure for 1 or 2 minutes while keeping the eye closed without blinking. Then wash your hands again. Make sure that the tip of the dropper does not touch your eye, finger, or any other surface.

Overdose Symptoms
No specific ones have been reported.

What to Do
An overdose of brinzolamide is unlikely to be life-threatening. If a large volume enters the eye, flush with water. If someone accidentally ingests the medicine, call your doctor, emergency medical services (EMS), or the nearest poison control center.

Drug Interactions
Wait 10 minutes before administering any other eye medicine. Brinzolamide should not be used in conjunction with oral carbonic anhydrase inhibitors. People allergic to sulfa-type drugs should not use brinzolamide.

Food Interactions
No known food interactions.

Disease Interactions
Do not use if you have severe kidney impairment. Use with caution if you have liver disease.

Date Published: 04/13/2005
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