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Side Effects
Serious

Shortness of breath, wheezing; irregular or slow heartbeat (50 beats per minute or less); pain or feelings of tightness or pressure in the chest; swelling of the ankles, feet, and lower legs; mental depression. If you experience such symptoms, stop taking bisoprolol and call your doctor immediately.
Common

Dizziness or lightheadedness, especially when rising suddenly to a standing position; rapid heartbeat or palpitations; decreased sexual ability; unusual fatigue, weakness, or drowsiness; insomnia.
Less Common

Anxiety, irritability, nervousness; constipation; diarrhea; dry, sore eyes; itching; nausea or vomiting; nightmares or intensely vivid dreams; numbness, tingling, or other unusual sensations in the fingers, toes, or scalp.
Bisoprolol Fumarate


Drug Class:
Beta-blocker

Available OTC?: No

Available Generic?: No

Zebeta 5 mg
(Lederle)
Available In
Why Prescribed
How It Works
Range and Frequency
Onset of Effect
Duration of Action
Dietary Advice
Storage
Missed Dose
Stopping the Drug
Prolonged Use
Over 60
Driving and Hazardous Work
Alcohol
Pregnancy
Breast Feeding
Infants and Children
Special Concerns
Overdose Symptoms
What to Do
Drug Interactions
Food Interactions
Disease Interactions
 


Available In
Tablets

Why Prescribed
To control hypertension (high blood pressure).

How It Works
Bisoprolol slows the rate and force of contraction of the heart by blocking certain nerve impulses, thus reducing blood pressure.

Range and Frequency
Starting dose is 5 mg once a day, or 2.5 mg once a day for those with kidney or liver problems. If necessary, it may be increased gradually to 20 mg once a day. Maximum dose is 20 mg per day.

Onset of Effect
Within 1 to 4 hours.

Duration of Action
24 hours.

Dietary Advice
Take this drug at mealtime or immediately afterward.

Storage
Store in a tightly sealed container away from heat and direct light.

Missed Dose
If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose and return to your regular schedule. Do not double the next dose.

Stopping the Drug
Do not stop taking this drug without consulting your doctor. It may be necessary to reduce the dosage gradually to prevent adverse effects.

Prolonged Use
Ask your doctor about the need for medical examinations or laboratory studies of your heart, blood pressure, kidney function, and blood sugar. Monitor your blood pressure often.

Over 60
Adverse reactions and side effects may be more common in older persons.

Driving and Hazardous Work
Determine how bisoprolol affects you before driving or engaging in any hazardous activities.

Alcohol
Drink in careful moderation if at all. Alcohol may interact with the drug and cause a dangerous drop in blood pressure.

Pregnancy
Be sure to notify your doctor promptly if you are pregnant or plan to become pregnant. Use bisoprolol during pregnancy only if the expected benefits outweigh the possible risks.

Breast Feeding
Bisoprolol passes into breast milk. Do not use it while you are breast feeding.

Infants and Children
Your pediatrician must determine the correct dose for a child.

Special Concerns
Prior to any dental or medical procedure or test, be sure to tell the doctor or dentist that you are taking bisoprolol. This drug may mask exercise-induced chest pain (angina). Ask your doctor for advice on a safe exercise program. Dress warmly in cold weather.

Overdose Symptoms
Asthma-like attacks (wheezing, breathlessness), very slow pulse, extreme shortness of breath associated with congestive heart failure.

What to Do
Call your doctor, emergency medical services (EMS), or the nearest poison control center immediately.

Drug Interactions
Consult your doctor if you are taking any other blood pressure drug or beta-blocker. Be sure to check with your doctor before taking any over-the-counter medication, especially diet aids or cold preparations, as these may contain ingredients that can interact adversely with bisoprolol.

Food Interactions
None are expected, unless you are allergic to certain foods, as this medicine may cause allergic reactions to be more severe.

Disease Interactions
Bisoprolol should be used with caution in people with diabetes, especially insulin-dependent diabetes, since the drug may mask symptoms of hypoglycemia. Consult your doctor if you have a medical history of heart disease, asthma, blood vessel (vascular) disease, or thyroid disease. Diabetic patients must monitor their blood glucose (sugar) levels closely.

Date Published: 04/13/2005
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