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Drugs

Side Effects
Serious

Irregular, rapid, or labored breathing, lightheadedness or sudden fainting, seizures, joint pain, fever, severe abdominal pain and cramping with watery or bloody stools, severe allergic reaction (marked by sudden swelling of the lips, tongue, face, or throat; breathing difficulty; skin rash, itching, or hives), unusual bleeding or bruising, yellowish tinge to eyes or skin. Call your doctor immediately.
Common

Rash, mild diarrhea, nausea, vomiting, headache, vaginal discharge and itching, pain or white patches in the mouth or on the tongue.
Less Common

Weakness, fatigue.

 

Amoxicillin/Potassium Clavulanate


Drug Class:
Penicillin antibiotic combination

Available OTC?: No

Available Generic?: No

Augmentin 500/125 mg
(SmithKline Beecham)
Available In
Why Prescribed
How It Works
Range and Frequency
Onset of Effect
Duration of Action
Dietary Advice
Storage
Missed Dose
Stopping the Drug
Prolonged Use
Over 60
Driving and Hazardous Work
Alcohol
Pregnancy
Breast Feeding
Infants and Children
Special Concerns
Overdose Symptoms
What to Do
Drug Interactions
Food Interactions
Disease Interactions


Available In
Tablets, chewable tablets, oral suspension

Why Prescribed
To treat a variety of bacterial infections, including those of the sinuses and middle ear, skin and soft tissues, genitourinary tract, and the respiratory tract. The medication is effective only against infections caused by bacteria, not against those caused by viruses, fungi, or other microorganisms.

How It Works
Amoxicillin blocks the formation of bacterial cell walls, rendering bacteria unable to multiply and spread. Clavulanate enhances the effectiveness of amoxicillin by inhibiting the activity of a specific enzyme (beta-lactamase) produced by certain drug-resistant strains of bacteria.

Range and Frequency
Tablets:  Adults and children more than 88 lbs: 250 to 500 mg of amoxicillin with 125 mg of clavulanate every eight hours. Children up to 88 lbs: 6.7 to 13.3 mg of amoxicillin with 1.7 to 3.3 mg of clavulanate per 2.2 lbs (1 kg) of body weight every eight hours. Chewable tablets and oral suspension; Adults and children more than 88 lbs: 250 to 500 mg of amoxicillin with 62.5 to 125 mg of clavulanate every eight hours. Children up to 88 lbs: 6.7 to 13.3 mg of amoxicillin with 1.7 to 3.3 mg of clavulanate per 2.2 lbs (1 kg) of body weight every 8 hours. Newer dosage for adults: 875 mg of amoxicillin with 125 mg of clavulanate twice a day.

Onset of Effect
One to two hours.

Duration of Action
Six to eight hours.

Dietary Advice
Best taken on an empty stomach, but may be taken with food to minimize stomach irritation or diarrhea.

Storage
Store in a tightly sealed container away from heat and direct light. Keep the liquid form refrigerated, but do not allow it to freeze.

Missed Dose
Take it as soon as you remember unless it is almost time for the next dose. In that case, skip the missed dose and take the next one. Do not double the next dose.

Stopping the Drug
Take this medication as prescribed for the full treatment period, even if you begin to feel better before the scheduled end of therapy.

Prolonged Use
Prolonged use can make you more susceptible to bacterial or fungal infections (such as yeast infections).

Over 60
No special problems are expected.

Driving and Hazardous Work
Do not drive or engage in hazardous work until you determine how the medicine affects you.

Alcohol
No special precautions are necessary.

Pregnancy
Limited studies have found no evidence of birth defects. Consult your doctor if you are pregnant or plan to become pregnant.

Breast Feeding
Amoxicillin/clavulanate may pass into breast milk and cause problems in the nursing infant; avoid use while breast feeding.

Infants and Children
No special problems are expected.

Special Concerns
Those who are prone to asthma, hay fever, hives, or allergies may be more likely to have an allergic reaction to a penicillin antibiotic. If severe diarrhea occurs as a side effect of this drug, do not take antidiarrheal medications; call your doctor for advice instead. This drug can cause false results on some urine sugar tests for patients who have diabetes.

Overdose Symptoms
Severe diarrhea, nausea, unusual excitability, seizures, or vomiting.

What to Do
Call your doctor, emergency medical services (EMS), or the nearest poison control center immediately.

Drug Interactions
Consult your doctor for advice if you are taking erythromycins, disulfiram, anticoagulants, tetracyclines, oral contraceptives, or gout drugs.

Food Interactions
None expected.

Disease Interactions
Consult your doctor if you have a history of allergies, asthma, congestive heart failure, gastrointestinal disorders (especially colitis associated with the use of antibiotics), or impaired kidney function.

Date Published: 04/13/2005
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