Phone

Drugs

Side Effects
Serious

Slow heartbeat, difficulty breathing, mental depression, cold hands and feet, swelling of ankles, feet, or lower legs. Call your doctor immediately.
Common

Dizziness or lightheadedness, decreased sexual ability, drowsiness, insomnia, fatigue, diarrhea.
Less Common

Anxiety, loss of appetite, upset stomach, nervousness or excitability, constipation, numbness and tingling in the fingers and toes, stuffy nose.
Bisoprolol Fumarate/Hydrochlorothiazide


Drug Class:
Beta-blocker/thiazide diuretic

Available OTC?: No

Available Generic?: No

Available In
Why Prescribed
How It Works
Range and Frequency
Onset of Effect
Duration of Action
Dietary Advice
Storage
Missed Dose
Stopping the Drug
Prolonged Use
Over 60
Driving and Hazardous Work
Alcohol
Pregnancy
Breast Feeding
Infants and Children
Special Concerns
Overdose Symptoms
What to Do
Drug Interactions
Food Interactions
Disease Interactions


Available In
Tablets

Why Prescribed
To control hypertension (high blood pressure).

How It Works
Bisoprolol, a beta-blocker, blocks certain nerve impulses to various parts of the body, which accounts for its many effects. For example, it reduces the rate and force of the heart's contractions (which helps to lower blood pressure), decreases the heart's oxygen requirement (which helps prevent angina) and helps stabilize heart rhythm. Hydrochlorothiazide (HCTZ), a diuretic, increases the excretion of salt and water in the urine. By reducing the overall amount of fluid in the body, diuretics reduce pressure within the blood vessels.

Range and Frequency
Tablets contain 6.25 mg HCTZ and 2.5, 5, or 10 mg bisoprolol. Therapy is initiated with the lowest dose and may be increased at 1 week intervals to 2 tablets with 10 mg bisoprolol once a day.

Onset of Effect
Within 1 to 4 hours.

Duration of Action
Up to 24 hours.

Dietary Advice
No special restrictions.

Storage
Store in a tightly sealed container away from heat, moisture, and direct light.

Missed Dose
If you miss a dose on one day, resume your regular dosage schedule the next day. Do not double the next dose.

Stopping the Drug
The decision to stop taking the drug should be made in consultation with your physician. Do not stop taking this drug abruptly; your doctor will gradually decrease your dose before stopping completely.

Prolonged Use
Bisoprolol/hydrochlorothiazide can control high blood pressure, but cannot cure it. Lifelong therapy may be necessary. See your doctor regularly for tests and examinations if you must take this drug for a prolonged period of time.

Over 60
Adverse reactions, especially dizziness, lightheadedness, and reduced tolerance to cold, may be more likely and more severe in older patients.

Driving and Hazardous Work
Do not drive or engage in hazardous work until you determine how the medicine affects you.

Alcohol
Drink in careful moderation if at all. Alcohol may interact with the bisoprolol component and cause a dangerous drop in blood pressure.

Pregnancy
Beta-blockers and thiazide diuretics may cause problems during pregnancy. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant.

Breast Feeding
This drug passes into breast milk; caution is advised. Consult your doctor for specific advice.

Infants and Children
Adequate studies have not been done on the use of this drug in children. No special problems are expected. Consult your pediatrician for advice.

Special Concerns
In addition to taking this medicine, follow your doctor's instructions on weight control and diet for reduction of blood pressure.

Overdose Symptoms
Slow heartbeat, severe dizziness or fainting, difficulty breathing, bluish-colored fingernails or palms of hands, seizures.

What to Do
Call your doctor, emergency medical services (EMS), or the nearest poison control center immediately.

Drug Interactions
Do not take with other beta-blockers. Consult your doctor for specific advice if you are taking any other antihypertensive medications, oral diabetes medications, insulin, digitalis drugs, cholestyramine, colestipol, clonidine, lithium, nonsteroidal anti-inflammatory drugs, MAO inhibitors, rifampin, narcotic analgesics, or skeletal muscle relaxants.

Food Interactions
Avoid foods high in sodium.

Disease Interactions
Do not use if you have a history of bronchospasm. Consult your doctor if you have any of the following: bronchial asthma, emphysema, slow heartbeat, heart or blood vessel disease, diabetes mellitus, congestive heart failure, gout, kidney disease, liver disease, depression, parathyroid disease, or an overactive thyroid (hyperthyroidism).

Date Published: 04/13/2005
Previous  |  Next
> Printer-friendly Version