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borage oil

What Is It?
Health Benefits
Forms
Dosage Information
Guidelines for Use
General Interaction
Possible Side Effects
Cautions
References
Evidence Based Rating Scale


What Is It?

From its bristly stems to its blue star-shaped flowers, virtually all parts of the borage plant (Borago officinalis) have been used over the centuries for their healing properties and as a flavoring for foods. As early as the 1600s, Europeans mixed borage leaves and flowers into a wine that was renown for relieving boredom and dispelling melancholy.

While modern science has found little evidence that the Herb itself has any therapeutic effects, its seed oil does appear to help in treating a number of conditions, from rheumatoid arthritis to menstrual problems. Research has shown that borage oil's medicinal effects can be traced to its rich stores of a therapeutic Fat called gamma linolenic acid (GLA).

Health Benefits

Like evening primrose oil and black currant seed oil, borage oil owes its healing power to the presence of essential fatty acids, the most important of which is GLA, an omega-6 fatty acid. (While borage oil is often used interchangeably with evening primrose oil, ounce for ounce, borage oil boasts more than twice as much GLA.) Once processed by the body, GLA is converted into hormonelike substances that can either block Inflammation or promote it. In borage oil, the GLA seems to calm inflammation overall, making it an attractive treatment option for arthritis and other inflammatory conditions.

Complicating matters, however, is the presence in borage oil of other fatty acids that may interfere with GLA absorption. In addition, borage leaves and flowers contain potentially toxic substances (pyrrolizidine alkaloids, or PAs) which could, in theory, cause harm if ingested over long enough periods of time. Borage seed oil may also contain minute amounts of PAs. Adverse reactions to the PAs are not widespread, but based on these concerns, borage oil often rates second to evening primrose oil as the GLA supplement of choice. On the other hand, borage oil is cheaper, and in many cases you can use a lower dose of borage oil to produce a therapeutic effect.

Specifically, borage oil may help to:

  • Reduce the aches and pains of rheumatoid arthritis. Researchers from the University of Pennsylvania found that high doses of borage oil (1.4 grams a day) led to a significant reduction in pain and swelling in arthritic joints when compared with cottonseed oil, which has no GLA. (1) In a separate study, patients with active rheumatoid arthritis demonstrated fewer clinical signs of inflammation after taking GLA-rich capsules for several months, compared to those who took a Placebo. (2) Other researchers reported reduced damage to joint tissues--and less joint pain and swelling--in those rheumatoid arthritis sufferers given very high GLA doses in the form of borage oil.

  • Relieve the discomforts of PMS, endometriosis, and fibrocystic breasts. By interfering with the production of inflammatory substances called Prostaglandins, which are released during menstruation, the GLA in borage oil may help ease related cramping and pain. Borage oil may also reduce some of the breast tenderness that women feel before their periods and calm endometriosis-associated inflammation. (3) Many PMS sufferers are found to have unusually low levels of GLA in their systems, which is why supplements may help so much. In women with fibrocystic breasts, the oil's essential fatty acids can minimize breast inflammation and promote the absorption of iodine, a Mineral often found in abnormally low levels in those with this condition. While various studies suggest that GLA-dense oils can effectively treat PMS discomforts, more recent research has cast some doubt on these claims.

  • Reduce the symptoms of eczema and psoriasis. In some cases, skin disorders develop when the body has problems converting dietary fats into GLA. Getting supplemental GLA from borage oil may therefore be helpful. (4) GLA and other essential fatty acids also revitalize the skin by quieting inflammation and causing blood vessels to contract. (5) People who suffer from the redness, itching, and other discomforts of eczema may even tolerate reduced doses of steroid creams and drugs--many of which cause unpleasant side effects--if they also take GLA. Not all studies point to such benefits, however, and many conventional doctors remain skeptical.

  • Clear up acne and rosacea. By working to dilute sebum, a thick oily substance that is overly secreted in some people with acne, the essential fatty acids in borage oil may reduce the risk of pores becoming clogged and lesions developing. The oil's essential fatty acids help treat rosacea by reducing inflammation, controlling the cells' use of nutrients, and by producing prostaglandins, which stimulate the contraction of blood vessels. Astringent substances in borage called tannins may also help by tightening skin. (6)

  • Alleviate inflammation associated with lupus. Inflammation in the kidneys, joints, skin, and other areas of the body caused by this condition may subside as a result of borage oil's anti-inflammatory actions as shown in mouse studies. (7)

  • Prevent nerve damage (neuropathy) due to diabetes. People with diabetes are more likely to lose feeling in their sensory nerves, which can lead to tingling and numbness in the arms and legs. An inability to convert GLA may be one reason for this. When diabetes patients are given GLA-rich evening primrose oil, nerve damage (neuropathy) symptoms improve. For reasons that remain unclear, borage oil has not proven as effective for this condition as evening primrose oil despite its higher concentrations of GLA. (8)

  • Combat damage from multiple sclerosis. The abundant supply of essential fatty acids in borage oil may be valuable in minimizing the inflammation associated with this progressive nerve disorder. The fatty acids may also contribute to healthy nerve development when taken over time. It is important to begin taking borage oil as soon as possible after diagnosis. (9)

  • Ease cough and soothe throat disorders. Borage oil has long been used in folk medicine to treat respiratory conditions, including coughs and sore throats. Besides GLA, borage oil also contains mucilage, a gummy, gel-like substance that soothes Mucous membranes often irritated by a cough. Mucilage also works as an expectorant, making it easier to cough up Mucus. According to a recent study from Ohio State University, patients with acute breathing problems needed fewer days on ventilation and spent less time in the hospital after taking fish oil and borage oil than those who went without these supplements. (10)

  • Treat Alzheimer's-related memory deficiencies. By boosting the transmission of nerve impulses, borage oil may be valuable in treating this progressive brain disorder.

  • Reduce stress and high blood pressure. Research on animals suggests that borage oil may protect against high blood pressure (Hypertension). (11, 12) Less is known about whether it affects blood pressure in humans, but in a study of 10 men who underwent stressful situations, borage oil limited stress-related jumps in blood pressure and heart rate. By relieving tension, borage oil also made it easier for men to perform normal tasks. (13)

  • Nourish nails, scalp, and hair. The rich stores of essential fatty acids in borage oil not only prevent nails from cracking but also help to keep them generally healthy. In addition, the essential fatty acids nourish the scalp, making the supplement potentially valuable in treating a variety of hair problems.

  •  Treat gout. Borage oil's anti-inflammatory actions--largely a function of its GLA stores--make it potentially valuable in protecting against the sudden and severe joint pain caused by uric acid buildup, which is known as gout.

  • Counter impotence and female infertility. By promoting blood flow, the GLA in borage oil can help treat a primary cause of male impotence--compromised circulation leading to impaired penile blood flow. In addition, when the oil is taken long term, GLA can help prevent blood vessel narrowing, often a consequence of plaque buildup from high cholesterol. By improving uterine function, GLA may also help women who are unable to conceive.

    Note: Borage oil has also been found to be useful for a number of other disorders. For information on these additional ailments, see our Dosage Recommendations Chart for Borage Oil.

  • Forms

    • softgel
    • oil
    • capsule

    Dosage Information

    For the majority of ailments mentioned: Take 1,000 to 1,300 mg of borage oil daily. This provides 240 to 300 mg of GLA (respectively), the main healing ingredient. Nearly equivalent doses of GLA can be found in 3,000 mg of evening primrose oil or 1,500 mg of black currant seed oil.

    Special tip:

  • While research studies tend to use relatively high dosages of borage oil, it's important to stick to standard, recommended dosages because the potential health hazards associated with excessive or prolonged use of borage seed oil are still unproved.

    Be sure to check out our Dosage Recommendations Chart for Borage Oil, which lists therapeutic dosages for specific ailments at a glance.

  • Guidelines for Use

  •  Taking borage oil with food may boost GLA absorption and minimize unpleasant side effects.

  • General Interaction

  •  If you take an anticoagulant (blood-thinning) medication, check with your doctor before trying borage oil.

  • The are no other known drug or nutrient interactions associated with borage oil.

    For information on interactions with specific generic drugs, see our WholeHealthMD Drug/Nutrient Interactions Chart.

  • Possible Side Effects

  •  Borage oil may cause loose stools and minor stomach problems.

  •  The GLA in borage seed oil can inhibit platelet aggregation, so it may prolong bleeding time and increase the risk of bruising and bleeding.

  •  One of the PAs identified in borage seed oil--the unsaturated PA, amabiline--has been shown in very high doses to damage the liver. It may have cancer-causing properties as well. Just how much of this toxic substance is present in borage seed oil--if any at all (it's measured in parts per billion)--remains unclear.

  • Cautions

  •  Although a possible alternative to evening primrose oil, far less information is available on the safety and effectiveness of borage oil.

  •  Because of the still-unproved but theoretical risk for liver damage posed by the PAs in borage oil, people with liver problems may want to use evening primrose oil instead.

  •  Only use borage oil in high doses or over a number of months if you're under a doctor's supervision. Periodic liver function tests would be a wise precaution.

  •  Because of its unproved but potential health risks, a number of countries disapprove of the use of borage (the oil and herb) as a medical treatment. Others, including Germany, have established standards for the maximum amount of PAs allowed in borage products.

  • Largely because the risks of using borage oil are still unknown, pregnant or nursing women should avoid this herb.

  •  The stems and leaves of borage herbs are tasty, but they contain relatively high concentrations of toxic PAs; therefore don't consume them in large amounts. And don't rub the herb directly on open cuts or irritated skin.
  • References 

    1. Leventhal LJ, Boyce EG, Zurier RB. Treatment of rheumatoid arthritis with gammalinolenic acid. Ann Intern Med. 1993 Nov 1;119(9):867-73.

    2. Zurier RB, Rossetti RG, Jacobson EW, et al. Gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. Arthritis Rheum. 1996 Nov;39(11):1808-17.

    3. Belch JJ, Hill A. Evening primrose oil and borage oil in rheumatologic conditions. Am J Clin Nutr. 2000 Jan;71(1 Suppl):352S-6S.

    4. Henz BM, Jablonska S, van de Kerkhof PC, et al. Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. Br J Dermatol. 1999 Apr;140(4):685-8.

    5. Ben-Shabat S, Benisty R, Wormser U, Sintov AC. Vitamin D3-based conjugates for topical treatment of psoriasis: synthesis, antiproliferative activity, and cutaneous penetration studies. Pharm Res. 2005 Jan;22(1):50-7.

    6. Liao S. Androgen action: molecular mechanism and medical application. J Formos Med Assoc. 1994 Sep;93(9):741-51.

    7. Godfrey DG, Stimson WH, Watson J, Belch JF, Sturrock RD. Effects of dietary supplementation on autoimmunity in the MRL/Ipr mouse: a preliminary investigation. Ann Rheum Dis. 1986 Dec;45(12):1019-24.

    8. Dines KC, Cotter MA, Cameron NE. Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. Prostaglandins Leukot Essent Fatty Acids. 1996 Sep;55(3):159-65.

    9. Harbige LS, Layward L, Morris-Downes MM, Dumonde DC, Amor S. The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-beta1) upregulation and increased prostaglandin E2 (PGE2) production. Clin Exp Immunol. 2000 Dec;122(3):445-52.

    10. Gadek JE, DeMichele SJ, Karistad MD, et al. Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group. Crit Care Med. 1999 Aug;27(8):1409-20.

    11. Engler MM, Engler MB, Erickson SK, Paul SM. Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. J Hypertens. 1992 Oct;10(10):1197-204.

    12. Engler MM. Comparative study of diets enriched with evening primrose, black currant, borage or fungal oils on blood pressure and pressor responses in spontaneously hypertensive rats. Prostaglandins Leukot Essent Fatty Acids. 1993 Oct;49(4):809-14.

    13. Mills DE, Prkachin KM, Harvey KA, Ward RP. Dietary fatty acid supplementation alters stress reactivity and performance in man. J Hum Hypertens. 1989 Apr;3(2):111-6.


    Evidence Based Rating Scale
       

    The Evidence Based Rating Scale is a tool that helps consumers translate the findings of medical research studies with what our clinical advisors have found to be efficacious in their personal practice. This tool is meant to simplify which supplements and therapies demonstrate promise in the treatment of certain conditions. This scale does not take into account any possible interactions with any medication/ condition/ or therapy which you may be currently undertaking. It is therefore advisable to ask your doctor before starting any new treatment regimen.

    Condition

    Rating

    Explanation

     

     

     

      

     

     

     

    Acne

     

     

     

     

     

     

     

     

     

     

     

    Limited preliminary research has shown some efficacy. More research is needed to confirm or refute these initial findings.

     

     

     

     

     

     

      

     

    Cough/throat disorders

     

     

     

     

     

     

     

     

     

    High-quality studies have shown efficacy in reduction of duration in intensive care unit and of ventilator requirement in patients with acute respiratory distress syndrome.

     

     

     

     

     

     

     

    Eczema

     

     

     

     

     

     

     

     

    Some evidence of efficacy in relieving symptoms. But conflicting evidence indicates need for further research.

     

     

    Gout

     

     

    Anecdotal evidence suggests some efficacy. No clinical evidence exists to support these findings. More research is needed.

     

     

    Hypertension

     

     

     

     

     

     

    Physiologic studies have shown efficacy in animals and humans. More human trials are needed to confirm or refute these findings.

     

     

    Lupus

     

     

     

     

    Few trials have tested efficacy. More research is needed to confirm or refute efficacy.

     

    Multiple sclerosis

     

     

    Limited trials have shown efficacy as anti-inflammatory. Further research is needed to confirm or refute these preliminary findings. Typically only used by trained clinicians.

     

    Nail problems

     

    Favorable results in patients suggests efficacy in nourishing effect. More clinical research is needed to confirm these results.

     

    Neuropathy due to diabetes

     

    Some evidence of improving symptoms, but other sources of GLA have been shown to be more efficacious.

     

    PMS

     

    Limited trials indicate efficacy as anti-inflammatory, but conflicting evidence indicates need for further research.

     

    Psoriasis

     

    Limited trials indicate efficacy in relieving symptoms, but conflicting evidence indicates need for further research.

     

    Rheumatoid arthritis

     

    Multiple good-quality studies indicate efficacy.

     

    Rosacea

     

    Preliminary evidence has shown some efficacy. More research is needed to confirm or refute these findings.

     

     

    Ailments Dosage
    Acne
    1,000 mg a day (take as alternative to evening primrose oil)
    Alzheimer's Disease 1,000 mg a day
    Cough
    1,000 mg a day.
    Diabetes
    1,000 mg a day (contains 300 mg gamma-linoleic acid)
    Eczema 1,000 mg a day
    Endometriosis
    1,000 mg a day
    Hair Problems 1,000 mg a day
    High Blood Pressure
    1,000 mg a day.
    Lupus 1,000 mg a day
    Nail Problems
    1000 mg a day, as alternative to flaxseed oil.
    Perimenopause
    1,000 mg a day; use as alternative to evening primrose oil
    PMS 1,000 mg a day
    Psoriasis 1,000 mg a day
    Raynaud's Disease
    Apply oil to the affected portion of skin every day.
    Rheumatoid Arthritis
    1,000 mg twice a day
    Sore Throat
    1,000 mg a day.
    Stress 1,000 mg a day

    Drug/Nutrient Interactions
    View Drug Interactions



    Date Published: 4/19/2005
    Date Reviewed: 10/23/2009



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