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DRUGS
Amitriptyline Hydrochloride - Drug Interactions
DMAE

Interaction with DMAE may lead to excessively high levels of acetylcholine.


kava
Excessive drowsiness may occur when taken together. Use with caution.

DLPA
Because DLPA exerts its effects through the central nervous system, avoid taking it with amitriptyline, unless specifically instructed to do so by your doctor.

5-HTP
Anxiety, confusion, or other serious side effects may occur if 5-HTP is taken with amitriptyline. Check with your doctor before combining.

melissa
Excessive drowsiness may occur when taken together. Use with caution.

St. John's wort
If you're already taking this antidepressant, don't add St. John's wort without consulting your doctor. The combination may lead to serious side effects. Both St. John's wort and this medication have photosensitivity (increased sensitivity to sunlight) as

valerian
Excessive drowsiness may occur when taken together. Use with caution.

melatonin
Excessive drowsiness may occur when taken together. Use with caution.

dandelion

Patients taking drugs metabolized by cytochrome P452 1A2 (CYP1A2), such as amitriptyline (Elavil),  should avoid taking dandelion. The plant may cause these drugs to inhibit CYP1A2 and to increase the levels of the drugs.


grapefruit seed extract

Grapefruit juice has a high probability of increasing the blood’s absorption of amitryptiline (Elavil) and should not be taken with it as there is a risk of overdose.


fiber, insoluble
Dietary fiber may lower the blood levels and effectiveness of tricyclic antidepressants, such as amitriptyline (Elavil).

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