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Fluconazole
Brand Name(s):
Diflucan
Drug Class:
Antifungal
Available OTC?: No
Available Generic?: No
Available In
Why Prescribed
How It Works
Range and Frequency
Onset of Effect
Duration of Action
Dietary Advice
Storage
Missed Dose
Stopping the Drug
Prolonged Use
Over 60
Driving and Hazardous Work
Alcohol
Pregnancy
Breast Feeding
Infants and Children
Special Concerns
Overdose Symptoms
What to Do
Drug Interactions
Food Interactions
Disease Interactions
 


Available In
Tablets, oral suspension, injection

Why Prescribed
To treat fungal infections of the mouth and throat (thrush), of the vagina (yeast infection), or throughout the body, as well as meningitis (Inflammation of the protective membranes surrounding the brain). Often used to treat AIDS-related fungal infections. May also be used to prevent recurring fungal infections in susceptible patients weakened by AIDS or by chemotherapy or radiation treatment.

How It Works
Fluconazole prevents fungal organisms from manufacturing vital substances required for their growth and function. This drug is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.

Range and Frequency
Adults and teenagers-- For fungal infections: 200 to 400 mg on the first day, then 100 to 400 mg once a day, using oral forms or injection. Injections are into a vein. For vaginal yeast infection: 1 dose of 150 mg, tablet or oral suspension.

Onset of Effect
Oral forms: Unknown. Injection: Immediate.

Duration of Action
Unknown.

Dietary Advice
Swallow tablets with liquid. Oral suspension should be shaken and carefully measured out before you take it. This drug can be taken without regard to diet.

Storage
Store in a tightly sealed container away from heat, moisture, and direct light. Keep any liquid form refrigerated, but do not allow it to freeze.

Missed Dose
Take it as soon as you remember. This will help keep a constant level of medication in your system. If it is near the time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose.

Stopping the Drug
Take it as prescribed for the full treatment period, even if you begin to feel better before the scheduled end of therapy. The decision to stop taking the drug should be made by your doctor. Gradual reduction of the dose may be necessary if you have been taking this medicine for a long time.

Prolonged Use
Notify your doctor if your condition does not improve, or instead becomes worse, within a few weeks.

Over 60
Dosage may need to be reduced in older patients with impaired kidney function.

Driving and Hazardous Work
The use of fluconazole should not impair your ability to perform such tasks safely.

Alcohol
No special precautions are necessary.

Pregnancy
Adequate studies of fluconazole use during pregnancy have not been done. Consult your doctor for specific advice if you are currently pregnant or plan to become pregnant.

Breast Feeding
Fluconazole may pass into breast milk; caution is advised. Consult your doctor for advice.

Infants and Children
Fluconazole is not generally prescribed for children under 14.

Special Concerns
Your doctor should monitor your kidney function while you take fluconazole. Tell any doctor or dentist whom you consult that you are taking this medicine. Be sure to shake the oral suspension well before taking it.

Overdose Symptoms
An overdose with fluconazole is unlikely.

What to Do
Emergency instructions not applicable.

Drug Interactions
Do not take cisapride with fluconazole. Other drugs may interact with fluconazole. Consult your doctor for specific advice if you are taking oral antidiabetic drugs, cyclosporine, rifampin, phenytoin, rifabutin, tacrolimus, astemizole, or warfarin.

Food Interactions
No food interactions have been reported.

Disease Interactions
Caution is advised when taking fluconazole. Consult your doctor if you have a history of alcohol abuse (and associated liver problems), or any type of liver or kidney disease, since these organs work together to remove the medication from the body.


Date Published: 4/14/2005
Date Reviewed: 4/14/2005


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Serious

Skin rash or itching, fever or chills. Call your doctor right away.
Common

No common side effects have been reported with the use of fluconazole.
Less Common

Diarrhea, nausea, vomiting, constipation, dizziness, headache, redness or flushing of skin.
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