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Idoxuridine (IDU)
Brand Name(s):
Herplex Liquifilm, Stoxil
Drug Class:
Ophthalmic antiviral drug
Available OTC?: No
Available Generic?: No
Available In
Why Prescribed
How It Works
Range and Frequency
Onset of Effect
Duration of Action
Dietary Advice
Storage
Missed Dose
Stopping the Drug
Prolonged Use
Over 60
Driving and Hazardous Work
Alcohol
Pregnancy
Breast Feeding
Infants and Children
Special Concerns
Overdose Symptoms
What to Do
Drug Interactions
Food Interactions
Disease Interactions


Available In
Drops, ointment

Why Prescribed
To treat viral infections of the eye, especially those caused by the herpes simplex virus.

How It Works
Idoxuridine interferes with the activity of enzymes necessary for the replication of viral DNA in cells, thus preventing the virus from multiplying.

Range and Frequency
The dosage may vary considerably from patient to patient, depending on a number of factors. The following guidelines represent typical doses. Follow your doctor's specific dosing instruction. Eye drops: Apply 1 drop in the eye every hour during the day and every 2 hours at night. When the condition improves, apply it every 2 hours during the day and every 4 hours at night. Ointment: Apply a 3/8-inch strip of ointment every 4 hours (5 times a day), making the last application at bedtime.

Onset of Effect
Within 1 hour.

Duration of Action
Up to 6 hours.

Dietary Advice
No special restrictions.

Storage
Keep the liquid form of idoxuridine refrigerated, but do not allow it to freeze.

Missed Dose
Apply the missed dose as soon as you remember. If it is near time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose.

Stopping the Drug
Take the drug as prescribed for the full treatment period, even if you begin to feel better before the scheduled end of therapy.

Prolonged Use
Idoxuridine is not intended for prolonged use. If your symptoms do not improve in 7 days, consult your physician.

Over 60
No special problems are expected.

Driving and Hazardous Work
The use of idoxuridine should not impair your ability to perform such tasks safely.

Alcohol
No special precautions are necessary.

Pregnancy
Before taking idoxuridine, tell your doctor if you are pregnant or plan to become pregnant.

Breast Feeding
Idoxuridine may pass into breast milk; caution is advised. Consult your doctor for advice.

Infants and Children
Studies of the use of idoxuridine specifically in children have not been done; this drug should be used by young patients only under close medical supervision.

Special Concerns
Be sure you know how to apply idoxuridine. For the eye drops, first wash your hands. Then apply pressure to the inside corner of the eye with your middle finger. Tilt your head backward and pull the lower lid away from the eye with the index finger of the same hand. Drop the eye drops into the pouch you have created and close your eyes without blinking. Keep your eyes closed for 1 to 2 minutes. Then wash your hands. For the ointment, first wash your hands. Pull the lower lid down from the eye to form a pouch. Squeeze the tube to apply a thin strip of the ointment into the pouch. Close your eyes for 1 to 2 minutes. Then wash your hands. Do not let the applicator touch any surface, including the eye. If you accidentally touch its tip, clean it with warm water and soap. Family members should use separate washcloths and towels to prevent the spread of infection.

Overdose Symptoms
No specific ones have been reported.

What to Do
An overdose of idoxuridine is unlikely to occur. Emergency instructions are not applicable.

Drug Interactions
Consult your doctor if you are using any eye product containing boric acid.

Food Interactions
No known food interactions.

Disease Interactions
Caution is advised when taking idoxuridine; consult your doctor if you have a history of any other eye problems.


Date Published: 4/14/2005
Date Reviewed: 4/14/2005


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Serious

Allergic reaction causing itching, swelling, redness, pain, and constant burning; corneal ulcer causing painful sensation of having something lodged in the eye. In either case, call your doctor or ophthalmologist immediately.
Common

Heightened sensitivity of the eyes to bright light, stinging or burning in the eyes.
Less Common

Blurred vision, excessive tear production.
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