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Itraconazole
Brand Name(s):
Sporanox
Drug Class:
Antifungal
Available OTC?: No
Available Generic?: Yes

Sporanox 100 mg
(Janssen)
Available In
Why Prescribed
How It Works
Range and Frequency
Onset of Effect
Duration of Action
Dietary Advice
Storage
Missed Dose
Stopping the Drug
Prolonged Use
Over 60
Driving and Hazardous Work
Alcohol
Pregnancy
Breast Feeding
Infants and Children
Special Concerns
Overdose Symptoms
What to Do
Drug Interactions
Food Interactions
Disease Interactions
 


Available In
Capsules, oral solution

Why Prescribed
To treat serious fungal infections occurring in the lungs and other parts of the body. These infections may occur in patients who do not have other illnesses, although they frequently occur in patients with weakened immune systems. Itraconazole is sometimes prescribed for fungal infections that are limited only to the nails.

How It Works
Itraconazole prevents fungal organisms from producing vital substances required for growth and function. This drug is effective only for infections caused by fungal organisms. It will not work against bacterial or viral infections.

Range and Frequency
Capsules-- Adults and teenagers 16 and older: 200 to 400 mg, taken once daily. Children under age 16: Consult your pediatrician for proper dosage. Oral solution-- Adults and teenagers: 100 to 200 mg once a day for days or weeks, depending on the condition being treated. Children: Consult your pediatrician. Swish the solution vigorously in your mouth for several seconds before swallowing.

Onset of Effect
Unknown.

Duration of Action
Unknown.

Dietary Advice
Take capsules with food, but do not take the oral solution with food. Maintain your usual food and fluid intake. Patients with immune system diseases are often weakened by their illness, by medications, or by other treatments, and may be unable to consume adequate amounts of nutritious food. Use liquid supplements if necessary.

Storage
Store in a tightly sealed container away from heat, moisture, and direct light.

Missed Dose
Take it as soon as you remember. This will help keep a constant level of medication in your system. If it is near the time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose.

Stopping the Drug
Take it as prescribed for the full treatment period, even if you begin to feel better before the scheduled end of therapy. The decision to stop taking the drug should be made by your doctor. Gradual reduction of the dose may be necessary if you have been taking this medicine for a long time.

Prolonged Use
Therapy with this medication may require months. Prolonged use may increase the risk of adverse effects.

Over 60
Adverse reactions may be more likely and more severe.

Driving and Hazardous Work
Do not drive or engage in hazardous work until you determine how the medicine affects you.

Alcohol
Avoid alcohol throughout therapy and for two days afterwards.

Pregnancy
Adequate studies of itraconazole use during pregnancy have not been done. Consult your doctor for specific advice if you are or are planning to become pregnant.

Breast Feeding
Itraconazole passes into breast milk; avoid or discontinue use while nursing.

Infants and Children
Itraconazole is not recommended for use by children under the age of 16.

Special Concerns
Women should use effective contraception to prevent pregnancy while taking this medication. Continue these measures for at least 2 months following the end of therapy. The capsules and the oral solution should not be used interchangeably.

Overdose Symptoms
An overdose with itraconazole is unlikely.

What to Do
Emergency instructions not applicable.

Drug Interactions
While taking itraconazole, do not take astemizole, cisapride, or terfenadine. Serious side effects involving the heart may result. You should not take medications containing alcohol, such as cough syrups, elixirs, and tonics. Consult your doctor for specific advice if you are taking antacids, anticholinergics, Histamine H2-blockers, omeprazole, oral antidiabetics, sucralfate, carbamazepine, cyclosporine, isoniazid, didanosine, digoxin, phenytoin, rifampin, or warfarin. If you are taking an antacid, take it at least 2 hours after taking itraconazole.

Food Interactions
No known food interactions.

Disease Interactions
Consult your doctor if you have any of the following conditions: liver or kidney disease, low levels or absence of stomach acid, or a history of alcohol abuse.


Date Published: 4/14/2005
Date Reviewed: 4/14/2005


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Serious

Skin rash or itching, fever or chills, unusual fatigue, loss of appetite, nausea, vomiting, yellow discoloration of the skin, dark urine, or pale stools. Call your doctor right away.
Common

No common side effects have been reported with the use of itraconazole.
Less Common

Diarrhea, nausea, vomiting, constipation, dizziness, headache, redness or flushing of skin.
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